2. Signaling Pathways
  3. Cell Cycle/DNA Damage
  4. Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Nucleoside Antimetabolite/Analog

Related Products

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Nucleoside analogues are molecules that act like nucleosides in DNA synthesis. They include a range of antiviral products used to prevent viral replication in infected cells. Nucleoside analogues can be used against hepatitis B virus, hepatitis C virus, herpes simplex, and HIV. Once they are phosphorylated, they work as antimetabolites by being similar enough to nucleotidesto be incorporated into growing DNA strands. Less selective nucleoside analogues are used as chemotherapy agents to treat cancer, eg gemcitabine and 5-FU. Antimetabolite is a chemical that inhibits the use of a metabolite, which is another chemical that is part of normal metabolism. Such substances are often similar in structure to the metabolite that they interfere with, such as the antifolates that interfere with the use of folic acid. The presence of antimetabolites can have toxic effects on cells, such as halting cell growth and cell division, so these compounds are used as chemotherapy for cancer.

Nucleoside Antimetabolite/Analog Related Products (2419):

Cat. No. Product Name Effect Purity Chemical Structure
  • HY-156998
    Troxacitabine triphosphate
    Troxacitabine triphosphate (TRX-TP) is a good substrate for replicative and repair DNA polymerases in vitro.
    Troxacitabine triphosphate
  • HY-178603
    3'-ONH₂-dUTP
    3'-ONH?-dUTP is a monomeric raw material that can be used for nucleic acid synthesis.
    3'-ONH₂-dUTP
  • HY-178661
    DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-phosphoramidite
    DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-Phosphoramidite is a monomeric raw material that can be used for nucleic acid synthesis.
    DMTr-2'-O-TOM-N2-MeOAc-N6-iBu-rA-3'-CE-phosphoramidite
  • HY-W740864
    7α,12α-Dihydroxy-5β-cholestan-3-one
    7α,12α-Dihydroxy-5β-cholestan-3-one is a nucleoside metabolite.
    7α,12α-Dihydroxy-5β-cholestan-3-one
  • HY-171533
    LNA-CTP
    LNA-CTP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-CTP
  • HY-137613B
    Rp-TTPαS
    Rp-TTPαS is a monomeric raw material that can be used for nucleic acid synthesis.
    Rp-TTPαS
  • HY-W870114
    N2-DMF-2'-O-Methylguanosine
    N2-DMF-2'-O-Methylguanosine is a monomeric raw material that can be used for nucleic acid synthesis.
    N2-DMF-2'-O-Methylguanosine
  • HY-152764
    4’-α-C-Methyluridine
    4’-α-C-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
    4’-α-C-Methyluridine
  • HY-177197
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine is a nucleotide analogue used in nucleic acid synthesis.
    5'-DMT-3'-CE-2'-TBDMS cyanoethoxycarbonyl-cytidine
  • HY-152654
    4′-Thiocytidine
    4′-Thiocytidine is a purine nucleoside analogue. Purine nucleoside analogs have broad antitumor activity targeting indolent lymphoid malignancies. Anticancer mechanisms in this process rely on inhibition of DNA synthesis, induction of apoptosis, etc.
    4′-Thiocytidine
  • HY-185479
    3'-O-Allyl-dCTP
    3'-O-Allyl-dCTP is a nucleotide analog that can be used for oligonucleotide synthesis.
    3'-O-Allyl-dCTP
  • HY-N8525
    3'-O-Acetylthymidine
    3'-O-Acetylthymidine, a purine nucleoside analog, is an inhibitor of ribonuclease A.
    3'-O-Acetylthymidine
  • HY-152303S
    N6-(4-Methoxybenzyl)adenosine-d3
    N6-(4-Methoxybenzyl)adenosine-d3 is deuterium labeled N6-(4-Methoxybenzyl)adenosine. N6-(4-Methoxybenzyl)adenosine is an adenosine analog. Adenosine analogs mostly act as smooth muscle vasodilators and have also been shown to inhibit cancer progression. Its popular products are adenosine phosphate, Acadesine (HY-13417), Clofarabine (HY-A0005), Fludarabine phosphate (HY-B0028) and Vidarabine (HY-B0277).
    N6-(4-Methoxybenzyl)adenosine-d<sub>3</sub>
  • HY-171532
    LNA-ATP
    LNA-ATP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-ATP
  • HY-154171
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one
    		99.87%
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one (Compound dP) exhibits mutagenicity for Escherichia coli and Salmonella typhimurium, that induces the conversion between GC and AT through replication error. eoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one is stable in Escherichia coli, and can be detected at wavelength >300 nM.
    Deoxyribosyl dihydropyrimido[4,5-c][1,2]oxazin-7-one
  • HY-178642
    3',5'-O-TIPDS-2'-spirocyclopropyl-U
    3',5'-O-TIPDS-2'-spirocyclopropyl-U is a monomeric raw material that can be used for nucleic acid synthesis.
    3',5'-O-TIPDS-2'-spirocyclopropyl-U
  • HY-137614C
    Rp-GTPαS tetrasodium
    Rp-GTPαS tetrasodium is a phosphorothioate analogue of Guanosine triphosphate (GTP) (HY-113225) that can activate calcium release and secretion in single rat peritoneal mast cells.
    Rp-GTPαS tetrasodium
  • HY-180366
    5-Amino-2'-deoxyuridine
    5-Amino-2'-deoxyuridine is a thymidine analogue and substrate for chemical reaction. 5-Amino-2'-deoxyuridine can be use in the preparation of labeled probes for DNA microarray analysis.
    5-Amino-2'-deoxyuridine
  • HY-171521
    LNA-GDP
    LNA-GDP is a nucleotide analog that can be used in the synthesis of oligonucleotides.
    LNA-GDP
  • HY-178585
    3′-O-Azidomethyl-dAMP
    3′-O-Azidomethyl-dAMP is a monomeric raw material that can be used for nucleic acid synthesis.
    3′-O-Azidomethyl-dAMP